Defective Degradation of Leukotrienes in Peroxisomal-Deficient Human Hepatocytes 161
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چکیده
منابع مشابه
Defective Peroxisomal Cleavage
Based on in vitro work with rat liver, we recently suggested that the peroxisomal fraction is most important for the oxidation of 3a,7a,12a-trihydroxy-5,8-cholestanoic acid (THCA) into cholic acid. The cerebro-hepato-renal syndrome of Zellweger is a fatal recessive autosomal disorder, the most characteristic histological feature of which is a virtual absence of peroxisomes in liver and kidneys....
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We studied the immune system, especially the chemotactic activity of neutrophils, in ten patients with vitamin D-deficient rickets and compared the results with ten healthy controls of matched age. Among all immune system factors, the chemotactic studies persistantly showed remarkable deficiency in leukocyte mobility, both random motion and migration. When compared with controls, the findi...
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Hepcidin, a circulating regulatory hormone peptide produced by hepatocytes, functions as the master regulator of cellular iron export by controlling the amount of ferroportin, an iron exporter present on the basolateral surface of intestinal enterocytes and macrophages. Hepcidin binding to ferroportin induces its internalization and degradation, resulting in cellular iron retention and decrease...
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4 Nicolas Ruggli*, Artur Summerfield, Ana R. Fiebach, Laurence Guzylack5 Piriou, Oliver Bauhofer, Catherine G. Lamm, Sandro Waltersperger, Keita 6 Matsuno, Luzia Liu, Markus Gerber, Kyung H. Choi, Martin A. Hofmann, 7 Yoshihiro Sakoda, and Jon-Duri Tratschin 8 9 Institute of Virology and Immunoprophylaxis, Mittelhäusern, Switzerland; Department of 10 Disease Control, Graduate School of Veterina...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1996
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199609000-00184